By Errol C Friedberg
With a Foreword by way of Sydney Brenner (Nobel laureate in body structure or drugs, 2002)
This biography info the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's lifestyles from start, in 1926, to the current, with distinct emphasis on his huge, immense clinical contributions, together with being the 1st to advance know-how that ended in gene cloning technology. In 1980, Berg obtained a Nobel Prize in chemistry for this work.
In addition to his contributions within the examine laboratory, Berg orchestrated and oversaw a historical assembly at Asilomar, California that headquartered on a threatening controversy surrounding the conception by means of a number of the destructive power of recombinant DNA know-how. This assembly did a lot to prevent this controversy and to install position the rules of recombinant DNA paintings, hence placing fears to rest.
The recombinant DNA controversy used to be a historical final result of the invention of gene cloning. particularly, it represented a paramount instance of medical foresight and due diligence by means of the clinical group, instead of by means of regulatory entities within the usa and lots of different international locations. the last word reputation of gene/DNA cloning ended in a brand new period of contemporary biology that prospers to the present.
This ebook is aimed essentially at scientists and people in education. The ebook strives to easily supply details for the final reader, yet isn't really in particular adapted for a normal studying audience.
While many books conceal the recombinant DNA controversy, none have satisfactorily addressed this ancient interval and are usually contradictory concerning the many who is, where's, and why's concerned. also, the nice majority of those have been written by means of non-scientists. This biography of Paul Berg presents entry to varied archived letters and files at Stanford collage no longer formerly addressed, and to the chronology of occasions as recalled and documented by way of him, in addition to different key personalities, lots of whom have been interviewed.
- Part I:
- Growing Up in Brooklyn
- The crucial Paul Berg
- College — and international warfare II
- Western Reserve University
- Part II:
- Washington collage, St. Louis
- Discovering move RNA
- Stanford college — and Its Refurbished division of Biochemistry
- Transcription and Translation: New Directions
- Part III:
- Making Recombinant DNA — the 1st Faltering Steps
- Making Recombinant DNA — a massive Breakthrough
- EcoRI restrict Endonuclease — an enormous Breakthrough
- “Coincidence is the observe We Use once we cannot See the Levers and Pulleys”
- Yet one other Stanford Contribution
- Part IV:
- An historical assembly in Hawaii
- The Recombinant DNA Controversy
- A Momentous Gordon examine Conference
- Making Recombinant Molecules with Frog DNA
- The Controversy Heats Up
- Asilomar II
- The Dissenters: a distinct aspect of View
- The Aftermath
- Legislative and Revisionist demanding situations to Recombinant DNA
- Asilomar II — classes Learned
- Part V:
- The Nobel Prize in Chemistry
- Commercializing the Technology
- Life is going on
- The “Retirement” Years
- Public coverage matters — and different Interests
- Personal Challenges
Readership: Researchers, graduate scholars, undergraduates in existence sciences, medication and chemistry and lay public.
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